Applications > Oligo aCGH > oligo aCGH Overview

Assessing Array CGH Platform Performance between Commercial Products
A review of Resolving the resolution of array CGH

A recent collaboration between researchers in British Columbia and The Netherlands (2007) compared array CGH performance between 10 different platforms, including the Agilent 244K microarray. The group characterized the various platforms through the introduction of "functional resolution" (a new metric that incorporates the distribution of array data points) and described a Java-based application "ResCalc," which automated the calculation of performance metrics for any aCGH platform (including any species and arrays covering only specific chromosomal segments). Results conclusively demonstrate that the Agilent oligo aCGH microarray exhibited the highest sensitivity of the oligonucleotide platforms...
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Cancer Research
Profiling Lung Cancer Mutations Using Oligo aCGH
A review of High-resolution genomic profiles of human lung cancer.
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High Resolution Characterization of a Common Genetic Alteration in Prostrate Cancer
A review of TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming.
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High Resolution Characterization of Multiple Myeloma using Array CGH
A review of Multiple myeloma primary cells show a highly rearranged unbalanced genome with amplifications and homozygous deletions irrespective of the presence of immunoglobulin-related chromosome translocations.
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Early Genetic Mutations Strongly Influence Later Cancer Phenotypes
A review of Heterogeneity of mammary lesions represent molecular differences.
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Elucidating the Mechanisms of Acute Myloid Leukemia
A review of Neurofibromatosis 1, and Not TP53, seems to be the main target of chromosome 17 deletions in de novo acute myeloid leukemia.
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Platform Performance
Assessing Array CGH Platform Performance between Commercial Products
A review of Resolving the resolution of array CGH.
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Comparing BAC and Oligo-Based Array CGH
A review of A new look towards BAC-based array CGH through a comprehensive comparison with oligo-based array CGH.
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A Systematic Comparison of Microarray Platforms for DNA Copy Number Profiling
A review of A Comparison of DNA Copy Number Profiling Platforms.
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Cytogenetics
Diagnosing Genetic Disease with CGH Microarrays
A review of Cryptic deletions are a common finding in "balanced" reciprocal and complex chromosome rearrangements: a study of 59 cases.
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Fine-scale mapping of human genome structural variation
A review of Mapping and sequencing of structural variation from eight human genomes.
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Discovering New Complexity in Human Copy-Number Variants
A review of The Fine-Scale and Complex Architecture of Human Copy-Number Variation.
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Getting to Know Craig Venter One Base at a Time
A review of The Diploid Genome Sequence of an Individual Human.
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Using aCGH to Expand Your Cytogenetic Research
A review of High-resolution global profiling of genomic alterations with long oligonucleotide microarray.
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